GRB10 interacting GYF protein 1 (GIGYF1)

GRB10 interacting GYF protein 1 (GIGYF1) is an adaptor protein belonging to the GYF family, characterized by a GYF protein interaction domain. GIGYF1 interacts with GRB10, an adaptor protein that modulates signaling downstream of the insulin and IGF-1 receptors. Through these interactions, GIGYF1 regulates receptor signaling, enhances insulin and IGF-1 receptor phosphorylation, and participates in metabolic and growth pathways. Beyond this, GIGYF1 is a translational repressor: it binds the translation initiation machinery (specifically, the eIF3 complex) and disrupts interactions necessary for efficient mRNA translation, notably repressing the production of certain transcripts such as interferon-β. GIGYF1 is broadly expressed and may play diverse roles in translational control, genome stability, and metabolic regulation. Loss-of-function mutations in GIGYF1 are associated with a range of disorders, from neurodevelopmental syndromes (including autism spectrum disorder) to metabolic dysfunction (including diabetes and altered glucose homeostasis). No approved drugs specifically target GIGYF1 at this time.

Other names

GRB10-interacting GYF protein 1GIGYF1CDS2PERQ1PP3360GYF1PERQ amino acid-rich with GYF domain-containing protein 1GYF domain containing 1postmeiotic segregation increased 2-like 12