GRB2-associated binding protein 3 (GAB3)

GRB2-associated binding protein 3 (GAB3) is a scaffolding adaptor protein belonging to the DOS/Gab family, found in humans and encoded by the GAB3 gene[1][8][10]. Members of this protein family play crucial roles in growth factor and cytokine signaling pathways by facilitating the assembly of signaling complexes through their pleckstrin homology (PH) domain and multiple phosphorylation and protein-interaction motifs[1][3][9]. GAB3 is highly expressed in hematopoietic tissues, such as spleen and thymus, with lower levels in other tissues, and is important in macrophage differentiation and immune response regulation, including for natural killer cell function during infection[3][4]. GAB3 participates in key signaling cascades, such as the PI3K/AKT and Ras-MAPK pathways, by interacting with proteins including GRB2 and SHP2 tyrosine phosphatase, and shares significant structural features with other Gab family members[3][10]. GAB3 has clinical relevance in cancer, where its expression may serve as a biomarker in lung adenocarcinoma and potentially modulate immunotherapy response; reduced GAB3 levels in tumors are linked to worse clinical outcomes[7]. The protein's molecular interactions and functions are being investigated for their roles in cancer, inflammation, and cardiovascular disease[6][7][10]. GAB3 does not currently have known direct drug interactions or mechanisms of action described for therapeutic targeting, nor are there recognized safety concerns specific to modifying GAB3 itself in a clinical context.

Other names

GRB2-associated binding protein 3GAB3GRB2-associated binder 3Gab3 scaffolding proteinDOS/Gab family member 3Growth factor receptor bound protein 2-associated protein 3