Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
GRB2-related adaptor protein-like (GRAPL)
- Target
- GRAPL
- Molecular classification
- Other (predicted signaling adaptor protein; not a classic receptor, enzyme, transporter, transcription factor, or ion channel)
01
Overview
GRB2-related adaptor protein-like (GRAPL) is a predicted human protein encoded by the GRAPL gene (GeneID: 400581) that is proposed to enable receptor tyrosine kinase binding and function as a signaling adaptor. Its sequence and domain structure suggest similarity to the GRB2 family of adaptor proteins, which are involved in signal transduction from receptor tyrosine kinases to downstream pathways. However, unlike well-characterized family members (e.g., GRAP, GRAP2), GRAPL lacks robust experimental data or validation of its biological role, interactions, or clinical significance. As such, GRAPL currently represents an annotation with little functional support, and its status as a protein-coding gene, adapter, or lncRNA remains unclear. This ambiguity is reinforced by confusion with other GRB2 family genes, whose signaling functions in immune cells and cancer have been established, unlike GRAPL.
- Other names
- GRB2-related adapter protein-likeGRAPLGRB2-related adapter protein LOC400581GRAPL long non-coding downstream RNAGRAPLDR
02
Mechanism of action
None reported
03
Biological functions
receptor tyrosine kinase bindingsignaling adaptor activitycell migrationenzyme-linked receptor protein signaling pathway
04
Disease associations
None validated; may have theoretical association with cell signaling pathways but no direct evidence for involvement in disease
Beyond the preview
Go deeper on GRB2-related adaptor protein-like (GRAPL).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on GRB2-related adaptor protein-like (GRAPL).