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GRIP and coiled-coil domain-containing protein 1 (GCC1)
- Target
- GCC1
- Molecular classification
- Other (Golgi-associated coiled-coil protein, peripheral membrane protein)
01
Overview
GRIP and coiled-coil domain-containing protein 1 is a peripheral membrane protein of the trans-Golgi network that contains a GRIP targeting domain and extensive coiled-coil regions. It functions in the organization of specific subcompartments of the trans-Golgi network involved in membrane trafficking and vesicle transport. It is sensitive to brefeldin A and may interact with other Golgi-localized proteins, including TRIM29, but is not a known direct therapeutic target[1][3][4][5][6].
- Other names
- GCC1GCC1PGCC88FLJ22035MGC20706Golgi coiled-coil protein 1peripheral membrane Golgi proteinGRIP and coiled-coil domain containing 1golgi coiled-coil 1
02
Biological functions
Organization of trans-Golgi networkmembrane transportmaintaining Golgi structure
03
Disease associations
Other (Associations reported with Charcot-Marie-Tooth disease, Phencyclidine abuse, but not established as a primary driver of major disease classes)
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