GRIP and coiled-coil domain-containing protein 2 (GCC2)

GRIP and coiled-coil domain-containing protein 2 (GCC2) is a peripheral membrane protein that localizes to the trans-Golgi network (TGN), characterized by a C-terminal GRIP domain involved in targeting and extensive coiled-coil regions. It is thought to regulate vesicular transport between endosomes and the Golgi by functioning as a tethering factor, especially in the recycling of the mannose 6-phosphate receptor from late endosomes to the TGN. GCC2 is also implicated in maintaining the organization, structure, and function of the Golgi apparatus, in part via recruitment of microtubule-stabilizing proteins. Mutations or dysregulation have been associated with certain cancers and Charcot-Marie-Tooth disease (axonal, type 2Z)[3][4][7].

Other names

KIAA0336RANBP2L4GCC185185 kDa Golgi coiled-coil proteinCLL-associated antigen KW-11CTCL tumor antigen se1-1Ran-binding protein 2-like 4renal carcinoma antigen NY-REN-53REN53