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Target intelligence / Profile preview
Group B Streptococcus capsular polysaccharide Ia (GBS CPS Ia)
- Target
- GBS CPS Ia
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Bacterial Antigen
01
Overview
Group B Streptococcus (GBS) capsular polysaccharide type Ia is a high-molecular-weight carbohydrate polymer that forms the outermost layer of the bacterial cell envelope of GBS serotype Ia. It is a major virulence factor, enabling GBS to evade host immune responses and contributing to its pathogenicity. It is composed of repeating pentasaccharide units containing glucose, galactose, N-acetylglucosamine, and sialic acid. Antibodies targeting this polysaccharide are protective, making it a key target for vaccine development.
- Other names
- Group B Streptococcus type Ia capsular polysaccharideGBS capsular polysaccharide IaCPS IaGBS Ia CPS
02
Mechanism of action
Antibodies targeting the capsular polysaccharide promote opsonophagocytosis and complement-mediated killing of GBS.
03
Biological functions
Immune evasionInhibition of complement activationResistance to phagocytosisBiofilm formationAdherence to host cells
04
Disease associations
Neonatal sepsisMeningitisPneumoniaInvasive Group B Streptococcal DiseaseInfection
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