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Target intelligence / Profile preview
Group B Streptococcus Capsular Polysaccharide Ib (GBS CPS Ib)
- Target
- GBS CPS Ib
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Glycan
01
Overview
Group B Streptococcus capsular polysaccharide type Ib (GBS CPS Ib) is a high-molecular-weight carbohydrate polymer that serves as a major virulence factor for the bacterium *Streptococcus agalactiae*. It inhibits phagocytosis and contributes to immune evasion, playing a critical role in the pathogenesis of neonatal sepsis and meningitis. GBS CPS Ib is a key target for vaccine development, with multivalent conjugate vaccines aiming to induce protective antibody responses against this and other serotypes.
- Other names
- Streptococcus agalactiae Capsular Polysaccharide IbGBS Type Ib CapsuleCPS Ib
02
Mechanism of action
Antibody-mediated opsonization and phagocytosis (via anti-CPS Ib antibodies)
03
Biological functions
Immune evasionAnti-phagocytic activityBiofilm formationPathogenesis
04
Disease associations
Neonatal sepsisNeonatal meningitisInvasive Group B Streptococcal DiseaseInfection
05
Safety considerations
Potential for serotype replacement with vaccine useNeed for multivalent vaccine coverageImmunogenicity limitations (addressed by conjugation)
06
Biomarkers
CPS Ib-specific antibodies (for vaccine efficacy)CPS Ib levels (in diagnostic assays)
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