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Target intelligence / Profile preview
Group B Streptococcus Capsular Polysaccharide III (CPS III)
- Target
- CPS III
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Bacterial Antigen
01
Overview
Group B Streptococcus capsular polysaccharide type III (CPS III) is a major virulence factor that enables the bacterium to evade host immune responses. It is a complex carbohydrate structure featuring unique glycosidic linkages and terminal sialic acids. The capsule shields GBS from phagocytosis and complement-mediated killing, contributing directly to bacterial persistence during infection. CPS III is a key target for vaccine development to prevent neonatal GBS infections.
- Other names
- GBS CPS IIIStreptococcus agalactiae Capsular Polysaccharide IIIType III Capsular Polysaccharide
02
Mechanism of action
Target for antibody-mediated neutralization; target for vaccine-induced antibody production.
03
Biological functions
Immune evasionProtection from phagocytosisComplement inhibitionAdhesionVirulence factor
04
Disease associations
Neonatal sepsisNeonatal meningitisInvasive Group B Streptococcal disease
05
Safety considerations
Potential for autoimmunity due to molecular mimicry with human glycansEfficacy of vaccine dependent on serotype distribution and coverage
06
Interacting drugs
Intravenous Immunoglobulin (IVIG)
1 more in the full profile.
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