Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Group IIA Secretory Phospholipase A2 (sPLA2-IIA)
- Target
- sPLA2-IIA
- Molecular classification
- Enzyme, Phospholipase, Secreted protein
01
Overview
Group IIA secretory phospholipase A2 (sPLA2-IIA) is an enzyme that catalyzes the hydrolysis of the sn-2 ester bond in glycerophospholipids, releasing free fatty acids and lysophospholipids. It plays a role in inflammatory responses and antimicrobial activity. Elevated levels are observed in various inflammatory diseases, making it a potential biomarker. sPLA2-IIA also induces production of VEGF-A and VEGF-C, implicating it in angiogenesis.
- Other names
- PLA2G2ASecretory Phospholipase A2 Group IIA
02
Mechanism of action
Hydrolyzes sn-2 ester bond in glycerophospholipids, releasing free fatty acids and lysophospholipids. Catalysis involves His48/Asp99/calcium complex.
03
Biological functions
Lipid metabolismHydrolysis of phospholipidsInflammatory responseAntimicrobial activityArachidonic acid releaseAngiogenesis
04
Disease associations
SepsisRheumatoid arthritisInflammatory bowel diseaseAcute coronary syndromeInflammationInfection
05
Safety considerations
Excessive activity can lead to uncontrolled inflammation
06
Biomarkers
Elevated levels in sepsisElevated levels in inflammatory diseases
Beyond the preview
Go deeper on Group IIA Secretory Phospholipase A2 (sPLA2-IIA).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Group IIA Secretory Phospholipase A2 (sPLA2-IIA).