Target intelligence / Profile preview

Group III metabotropic glutamate receptor 7 (mGluR7)

Target: mGluR7
Molecular classification: G protein-coupled receptor, GPCR, Class C GPCR

Overview

Metabotropic glutamate receptor 7 (mGluR7) is a G protein-coupled receptor that belongs to the group III mGluR family. It is primarily expressed in the central nervous system, particularly in the amygdala, hippocampus, and hypothalamus, where it functions as a presynaptic autoreceptor and heteroreceptor to inhibit the release of glutamate and GABA. mGluR7 has low affinity for glutamate and is implicated in neurodevelopmental disorders and seizure susceptibility. There are currently no approved drugs that directly target mGluR7.

Other names: GRM7MGLUR7GLUR7GPRC1G

Mechanism of action

Presynaptic inhibition of glutamate and GABA release.

Biological functions

Signal transductionInhibition of cyclic AMP cascadePresynaptic inhibition of neurotransmitter releaseAutoreceptor functionHeteroreceptor function

Disease associations

Neurodevelopmental disordersEpilepsySeizure susceptibility

Safety considerations

Potential for disrupting normal neurotransmitter balance if over-activated or inhibited.Low affinity for glutamate presents a challenge for drug development.

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