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Target intelligence / Profile preview
Group-specific antigen polyprotein (Gag)
- Target
- Gag
- Molecular classification
- Polyprotein, Structural protein
01
Overview
HIV-1 Gag (Group-specific antigen) is a polyprotein that plays a central and multifaceted role in the replication cycle of human immunodeficiency virus type 1 (HIV-1). It is essential for virion assembly, budding, release, and maturation. Initially considered merely a structural or scaffolding protein, extensive research has revealed that Gag orchestrates multiple critical steps in viral replication through its distinct domains.
- Other names
- HIV-1 GagPr55^Gag
02
Mechanism of action
Currently no approved antiretroviral drugs directly target HIV-1 Gag. Investigational inhibitors target capsid and maturation.
03
Biological functions
Virion assemblyMembrane targetingGenome packagingBuddingVirion releaseMaturation
04
Disease associations
InfectionHIV-1 infectionAIDS
05
Safety considerations
Potential for drug resistance mutations in GagOff-target effects due to interactions with host cell proteins
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