Growth arrest-specific 2-like protein 1 (GAS2L1)

Growth arrest-specific 2-like protein 1 is a multifunctional, evolutionarily conserved protein serving as a cytoskeletal cross-linker by binding both filamentous actin and microtubules via its calponin-homology (CH) and GAS2-related (GAR) domains. This enables GAS2L1 to regulate microtubule stability, guide microtubule growth along actin stress fibers, and contribute to the organization of stress fibers, focal adhesions, and cytoskeletal integrity. GAS2L1 localizes to the proximal end of mature centrioles, linking centrosomes to both microtubules and actin, and participates in proper centrosome disjunction, spindle assembly, and chromosome segregation. GAS2L1's activity is regulated through autoinhibition involving domain interactions, which is relieved by phosphorylation (e.g., at Ser352 by Nek2 during mitosis). There are isoforms of GAS2L1 resulting from alternative splicing, but its structure and function are mostly conserved within the GAS2 protein family. While GAS2L1 influences cell cycle and cytoskeletal organization, it is not currently a direct target for drug development or clinical intervention.

Other names

GAS2L1GAR22GAS2-related protein on chromosome 22Growth arrest-specific protein 2-like 1GAS2-like protein 1