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Target intelligence / Profile preview
Growth arrest-specific protein 6
- Molecular classification
- Vitamin K-dependent protein, Ligand, Plasma protein
01
Overview
Growth arrest-specific protein 6 (GAS6) is a vitamin K-dependent plasma protein that acts as a ligand for the TAM family of receptor tyrosine kinases (AXL, TYRO3, and MerTK). Through these receptors, it regulates various cellular processes, including cell growth, survival, adhesion, migration, platelet activation, vascular wall homeostasis, immune regulation, hepatic regeneration, and neuronal survival. Its involvement in hemostasis, inflammation, cancer, and viral infection makes it an attractive therapeutic target.
02
Mechanism of action
Modulation of GAS6/TAM receptor signaling (AXL, MerTK, TYRO3)
03
Biological functions
Cell growth and survivalCell adhesionCell migrationPlatelet activationThrombus formationVascular wall homeostasisImmune regulationHepatic regenerationNeuronal survival/migration
04
Disease associations
HemostasisInflammationCancerViral Infection
05
Safety considerations
Potential for off-target effects due to shared structural homology with protein SDysregulation leading to pro-thrombotic or pro-inflammatory states
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