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Growth Factor
- Molecular classification
- Protein, Steroid Hormone, Signaling Molecule
01
Overview
A growth factor is a naturally occurring substance, typically a protein or steroid hormone, that stimulates cell proliferation, differentiation, survival, wound healing, and tissue repair. Growth factors act as signaling molecules between cells and are crucial for regulating various cellular processes in both development and adult tissue maintenance. Examples include Epidermal Growth Factor (EGF), Fibroblast Growth Factors (FGF family), Platelet-Derived Growth Factor (PDGF), Nerve Growth Factor (NGF), Vascular Endothelial Growth Factor (VEGF), and Insulin-like Growth Factor (IGF).
02
Mechanism of action
Binding to specific cell surface receptors, activating intracellular signaling pathways leading to changes in gene expression.
03
Biological functions
Cell proliferationCell differentiationCell survivalWound healingTissue repairRegulation of inflammationAngiogenesis
04
Disease associations
CancerDevelopmental disordersDegenerative diseasesInflammation
05
Safety considerations
Uncontrolled proliferationOff-target effectsCytokine storm (in some cases)Resistance to therapy
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