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Target intelligence / Profile preview
Growth Factor Binding Protein (GFBP)
- Target
- GFBP
- Molecular classification
- Secreted protein, Growth factor regulator, Binding protein
01
Overview
Growth factor binding proteins (GFBPs) are a family of secreted proteins that primarily regulate the activity, bioavailability, and signaling of growth factors, most notably the insulin-like growth factors (IGFs). They bind to growth factors with high affinity, acting as transport proteins, regulating bioavailability by sequestering growth factors, and modulating signaling. Dysregulation of GFBPs is implicated in diseases such as cancer and metabolic disorders.
- Other names
- Insulin-like Growth Factor Binding ProteinIGFBP1IGFBP2IGFBP3IGFBP4IGFBP5IGFBP6IGFBP7MAC25TAF
02
Mechanism of action
Sequestration of growth factors, modulation of receptor activation, influencing cell proliferation, differentiation, and apoptosis
03
Biological functions
TransportStorageRegulation of bioavailabilityModulation of signalingCell proliferationCell differentiationApoptosis
04
Disease associations
CancerMetabolic disorders
05
Safety considerations
Dysregulation can lead to cancer progression or suppressionAltered levels linked to metabolic disorders
06
Biomarkers
GFBP levels in blood or tissue
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