Growth factor independent 1B transcriptional repressor (GFI1B)

Growth factor independent 1B transcriptional repressor (GFI1B) is a nuclear transcription factor characterized by a SNAG domain at the N-terminus and six C2H2 zinc finger domains at the C-terminus, enabling it to repress transcription of target genes through DNA binding and the recruitment of chromatin-modifying enzymes such as histone demethylases (e.g., LSD1), histone methyltransferases (e.g., G9A/EHMT2), and histone deacetylases (HDACs)[1][2][3][4]. GFI1B is crucial for erythroid and megakaryocytic differentiation, maintaining the fate and function of hematopoietic stem and progenitor cells, and repressing genes involved in apoptosis, proliferation, and differentiation[1][3]. Mutations or dysregulation of GFI1B contribute to hematologic cancers and inherited platelet disorders[1][2]. There are no approved drugs directly targeting GFI1B, though targeting its epigenetic partners is an area of active investigation[1][2][3][4].

Other names

Zinc finger protein Gfi-1bZNF163BGrowth factor independent protein 1BPotential regulator of CDKN1A translocated in CMLBDPLT17growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)growth factor independent 1B transcription repressorGFI1B

Inhibitors such as LSD1 inhibitors block the interaction of GFI1B with histone demethylases, modulating transcriptional repression on GFI1B target genes[1][2][3]. Modulation of epigenetic complexes (LSD1/HDAC/corepressors) to alter hematopoietic differentiation and proliferation.