Growth factor receptor-bound protein 10 (GRB10)

Growth factor receptor-bound protein 10 (GRB10) is an adaptor protein crucial for intracellular signal transduction. It is defined by its interaction with receptor tyrosine kinases such as the insulin receptor and IGF1 receptor, where it generally acts to inhibit downstream signaling and cell proliferation. GRB10 binds targets via its SH2 and BPS domains and is involved in growth suppression, regulation of metabolic insulin action, energy metabolism, and neuronal development. Highly regulated by genetic imprinting, GRB10 has tissue- and isoform-specific roles. Disease associations include Silver-Russell syndrome, cancer, diabetes, and cardiovascular disease. Experimental evidence shows that disruption of GRB10 results in altered growth, metabolic disturbance, and behavioral changes in animal models[1][2][3][5][6].

Other names

Insulin receptor-binding protein Grb-IRGrb-IRGRBIRKIAA0207Growth factor receptor-bound protein 10 adapter/adaptor proteinIRBPMEG1 (maternally expressed gene 1)RSS

Negative regulation of insulin and IGF-I signaling (GRB10 inhibits receptor kinase activity and blocks downstream signal transduction). Inhibition of growth factor receptor autophosphorylation. Modulation of ubiquitination and degradation of IGF1 receptor through the Grb10/Nedd4 complex.