Growth factor receptor-bound protein 7 (GRB7)

Growth factor receptor-bound protein 7 (GRB7) is an adaptor protein that contains Src homology 2 (SH2) and pleckstrin homology (PH) domains, enabling it to interact with receptor tyrosine kinases such as EGFR and ERBB2 (HER2), as well as focal adhesion kinase (FAK). GRB7 modulates key intracellular signaling pathways linked to cell migration, proliferation, and integrin signaling, with prominent roles in cancer cell invasion and metastasis. The GRB7 gene is frequently co-amplified with ERBB2 in multiple cancers and its overexpression is associated with poor patient prognosis, making it both a candidate prognostic biomarker and a potential therapeutic target, particularly in HER2-positive tumors. Experimental peptide inhibitors targeting the SH2 domain have shown preclinical anti-cancer activity by disrupting its protein-protein interactions, although no approved GRB7-specific drugs are available.

Other names

GRB7B47Epidermal growth factor receptor GRB-7GRB7 adapter proteingrowth factor receptor bound protein 7

Inhibition of GRB7 SH2 domain interaction with phosphorylated receptor tyrosine kinases (e.g., EGFR, ERBB2) to block downstream signaling and migration; suppression of integrin or focal adhesion signaling to reduce tumor cell invasiveness