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Target intelligence / Profile preview
C-X-C motif chemokine ligand 1 (CXCL1)
- Target
- CXCL1
- Molecular classification
- Chemokine, CXC Chemokine
01
Overview
CXCL1 is a small peptide belonging to the CXC chemokine family that primarily functions as a chemoattractant for neutrophils and other immune cells. It plays a key role in mediating leukocyte recruitment and activation to promote inflammation, wound healing, angiogenesis, and tumorigenesis. Elevated levels of CXCL1 have been observed in various pathological conditions, including chronic inflammation, fibrosis, cancer progression, and ischemia-reperfusion injury.
- Other names
- GRO1 oncogeneGrowth-regulated alpha proteinGROαGROAGRO oncogene
02
Mechanism of action
CXCL1 binds to CXCR2, a G protein-coupled receptor, activating intracellular signaling pathways including PI3Kγ/Akt, MAP kinases (ERK1/2), and PLCβ pathways, leading to further production of inflammatory cytokines.
03
Biological functions
Neutrophil chemoattractantLeukocyte recruitmentInflammationWound healingAngiogenesisVascular remodelingActivation of intracellular signaling pathways (PI3Kγ/Akt, MAP kinases (ERK1/2), PLCβ)
04
Disease associations
Chronic inflammationFibrosisCancer progressionColorectal cancerIschemia-reperfusion injury
05
Safety considerations
Aggravating tissue injury through inflammatory processesOverexpression linked with poor prognosis in certain cancers
06
Biomarkers
Elevated CXCL1 levels in various pathological conditionsCXCL1 expression in the cytoplasm of cancer cells
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