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Gse1 coiled-coil protein (GSE1)
- Target
- GSE1
- Molecular classification
- Other
01
Overview
Gse1 coiled-coil protein (GSE1) is a proline-rich protein containing coiled-coil domains, encoded by the GSE1 gene. It is thought to act as a subunit of the BRAF35-HDAC (BHC) histone deacetylase complex, thereby potentially regulating chromatin remodeling and gene transcription. Evidence suggests that GSE1 may function as an oncogene in breast cancer and its expression is elevated in some breast cancer patients. Disease associations include intraventricular meningioma, myoclonic cerebellar dyssynergia, and, from ortholog data, stomach cancer. While its precise molecular functions are not fully elucidated, GSE1 is not currently recognized as a direct receptor, enzyme, transporter, or established drug target in therapeutic settings
- Other names
- KIAA0182Genetic suppressor element 1
02
Biological functions
Protein binding (as a proline-rich, coiled-coil domain–containing protein, it may mediate protein–protein interactions)Component of chromatin remodeling complexes, specifically the BRAF35-HDAC (BHC) histone deacetylase complexPutative regulation of transcription through chromatin modification
03
Disease associations
Cancer (implicated in breast cancer as a potential oncogene, enhanced expression reported in breast cancer patients)Stomach cancer (mouse ortholog implicated, by inference from disease association data)Intraventricular meningiomaMyoclonic cerebellar dyssynergia
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