GSN antisense RNA 1 (GSN-AS1)

GSN antisense RNA 1 (GSN-AS1) is a long non-coding antisense RNA gene located on chromosome 9. It is not translated into protein and acts by regulating gene expression, often through epigenetic and transcriptional modulation. GSN-AS1 is upregulated in osteosarcoma and has been suggested as both a biomarker and therapeutic target for this cancer[1][3][5]. Its dysregulation has also been reported in other cancers, including downregulation in breast cancer. The precise biological mechanism often involves cis- or trans-regulation of gene expression, and it is part of a growing class of antisense long non-coding RNAs that play critical roles in cancer pathogenesis[1][4]. No current drugs directly target GSN-AS1, but its profile makes it a candidate for future RNA-based therapies.

Other names

C9orf31MOST2GSN antisense RNA 1GSN-AS1GSN antisense gene protein 1

Antisense RNA interaction, mainly affecting gene expression through cis or trans regulation, sometimes serving as a ceRNA or modulating the stability/transcription of target mRNAs