Target intelligence / Profile preview

GTP-binding protein 10 (GTPBP10)

Target: GTPBP10
Molecular classification: Enzyme (GTPase), Ribosome biogenesis factor, Obg family GTPase

Overview

GTP-binding protein 10 (GTPBP10) is a mitochondrial enzyme belonging to the Obg family of P-loop GTPases, structurally characterized by an N-terminal Obg domain and a C-terminal GTPase domain[2][3]. It serves a crucial role in the late stages of mitochondrial ribosomal large subunit (39S) maturation, associating with mitochondrial RNA granules and directly binding 16S rRNA[1][2]. GTPBP10 coordinates the correct assembly and accumulation of mitochondrial ribosomal subunits, enabling effective mitochondrial protein translation; its loss impairs mitochondrial gene expression and cellular energy metabolism[1][2][3]. No drugs are known to target GTPBP10, and it is not considered a therapeutic target at present.

Other names: GTPBP10ObgH2Protein obg homolog 2UG0751c10DKFZP686A10121FLJ38242LOC101927446GTP binding protein 10 (putative)

Mechanism of action

Not applicable (no known drugs targeting GTPBP10)

Biological functions

Mitoribosome assembly and maturation (especially the 39S mitochondrial large ribosomal subunit)Mitochondrial protein synthesis (indirectly, through ribosome assembly)RNA metabolism in mitochondria, especially 16S rRNA binding/maturationCoordination of mitochondrial ribosomal subunit accumulation

Disease associations

No direct disease association established; loss impairs mitochondrial function, with potential secondary links to mitochondrial diseases and metabolic dysfunction

Safety considerations

Mutational or functional loss of GTPBP10 impairs mitochondrial protein synthesis and cell growth, but there are no reports regarding drug safety concerns because there are no targeting drugs

Beyond the preview

Go deeper on GTP-binding protein 10 (GTPBP10).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on GTP-binding protein 10 (GTPBP10).

Explore the full profile