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GTP-binding protein GSPT1 (G1 to S phase transition 1) (GSPT1)
- Target
- GSPT1
- Molecular classification
- GTPase, Translation Termination Factor
01
Overview
GSPT1, also known as eukaryotic peptide chain release factor GTP-binding subunit ERF3A (eRF3a), is a GTPase that plays a critical role in translation termination during protein synthesis. It functions as part of the eRF1-eRF3-GTP ternary complex, which mediates translation termination at stop codons on mRNA. Targeting its degradation via cereblon modulators shows promise for treating hematologic malignancies.
- Other names
- GST1ETF3AeRF3a551G9.2G1 to S phase transition 1eukaryotic peptide chain release factor GTP-binding subunit ERF3A
02
Mechanism of action
Cereblon-dependent ubiquitination and degradation of GSPT1 via the CRL4(CRBN) E3 ubiquitin ligase pathway
03
Biological functions
Translation terminationCell growthCell survivalPolypeptide release
04
Disease associations
Cancer
05
Interacting drugs
CC-885
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