GTP binding protein overexpressed in skeletal muscle (GEM)

GTP binding protein overexpressed in skeletal muscle (GEM) is a member of the RAD/GEM family of small GTP-binding proteins, structurally related to the Ras superfamily[1][4][5][8]. GEM is associated with the inner face of the plasma membrane and is thought to act as a regulatory protein in receptor-mediated signal transduction, especially in the context of cytoskeletal organization and potentially in the modulation of voltage-dependent calcium channel activity[1][2][7]. The GEM gene undergoes alternative splicing but encodes the same protein through at least two transcript variants[4][5][8]. While GEM is not a direct pharmacological target or established therapeutic protein, changes in its expression have been observed in metabolic, neurological, and musculoskeletal disease contexts, indicating a possible role in disease biology rather than as a current intervention point[4][5][7][8].

Other names

GEMKIRKinase-inducible Ras-like proteinRAS-like protein KIRGTP-binding mitogen-induced T-cell proteinGTP-binding protein GEM

None established, since GEM is not a known direct pharmacological target[4][8].