GTPase, very large interferon-inducible pseudogene 1 (GVINP1)

GTPase, very large interferon-inducible pseudogene 1 (GVINP1) is classified as a **pseudogene** in humans, belonging to the very large inducible GTPase (VLIG) family and the TRAFAC class dynamin-like GTPase superfamily[10][5]. While homologous genes in other species (e.g., mouse Gvin1, chicken GVINP1) may encode large interferon-inducible GTPases implicated in immune functions, the human GVINP1 locus does not currently encode a functional protein, and its product is predicted solely based on sequence homology to have GTP binding capability[7][6][5]. There are no known drugs, biomarkers, or direct clinical applications for GVINP1, and it is not considered a therapeutic target. GVINP1 is associated in some studies as a susceptibility locus for lung cancer, but the biological mechanism remains uncharacterized[5]. Unlike functional interferon-inducible GTPases, which form antimicrobial complexes and are upregulated in response to interferons, GVINP1 in humans is annotated as a non-functional pseudogene, meaning it does not produce an active protein product[5][7][8].

Other names

Interferon-induced very large GTPase 1GVIN1GVIN1PVLIG1VLIG-1FLJ13373Very large inducible GTPase 1Interferon-induced very large GTPase pseudogene 1