GTPase activating protein and VPS9 domains 1 (GAPVD1)

GTPase activating protein and VPS9 domains 1 (GAPVD1) is a cytosolic protein that functions as both a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF)[1][3][9]. It activates Rab5 and Rab31, small GTPases involved in endocytosis and vesicle trafficking, and also exhibits GAP activity toward Ras[1][3]. GAPVD1 is essential for Rab5A activation during apoptotic cell engulfment and plays a role in EGFR trafficking and degradation[1][3]. It participates in insulin-stimulated plasma membrane phosphatidylinositol-3-phosphate formation, regulates LC2A4/GLUT4 trafficking, and is involved in endocytic transport[1][3][9]. Its dysfunction has been associated with hereditary steroid-resistant nephrotic syndrome and coenzyme Q10 deficiency[3]. No drugs or specific safety concerns are documented as of the latest available data.

Other names

GAPex-5RME-6Rab5-activating protein 6KIAA1521RAP6DKFZP434C212GAPEX5Rab5 exchange factorGAPD1_HUMAN