Target intelligence / Profile preview

GTPase HRas (HRas)

Target: HRas
Molecular classification: Small GTPase, Oncogene product, Signal transduction molecule

Overview

Ras proteins (p21^ras) are monomeric GTPases encoded by the HRAS, KRAS, and NRAS genes, functioning as molecular switches in signal transduction pathways that control cell proliferation, differentiation, and survival. Mutations in these proteins—especially KRAS—are among the most common drivers of human cancers, leading to constitutive activation of growth-promoting signaling cascades. Therapeutic targeting of mutant KRAS has become a major focus in oncology[6][9][7].

Other names: H-RasK-RasN-RasRas proteinsp21^ras

Mechanism of action

Direct inhibition of mutant KRAS proteins; Inhibition of farnesylation (membrane localization/blocking signaling)

Biological functions

Signal transductionRegulation of cell proliferationRegulation of cell differentiationMediation of growth factor signaling

Disease associations

CancerOther (rare developmental syndromes, e.g., Costello syndrome for HRAS)

Safety considerations

Drug resistance (secondary mutations)Wild-type Ras pathway effects (on-target toxicity)

Interacting drugs

Tipifarnib

3 more in the full profile.

Biomarkers

KRAS mutation status (especially G12C, G12D)HRAS/NRAS mutation detection in cancers

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