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Target intelligence / Profile preview
GTPase KRas G12V (KRAS G12V)
- Target
- KRAS G12V
- Molecular classification
- Small GTPase, Ras family protein
01
Overview
KRAS G12V is a constitutively active mutant of the KRAS protein, a small GTPase involved in cell signaling pathways regulating cell proliferation, differentiation, and survival. The G12V mutation impairs GTP hydrolysis, leading to persistent activation of downstream signaling pathways and uncontrolled cell growth, a hallmark of many cancers.
- Other names
- K-Ras 2 G12VKi-Ras G12Vc-K-ras G12Vc-Ki-ras G12VRASK2 G12VKRAS2 G12V
02
Mechanism of action
Inhibition of mutant-specific function or restoration of regulation lost due to impaired GAP sensitivity
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalRegulation of cell division
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effectsDevelopment of resistanceToxicity
06
Biomarkers
KRAS G12V mutation status
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