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GTSE1 divergent transcript (GTSE1-DT)

Target
GTSE1-DT
Molecular classification
Other (long noncoding RNA, lncRNA)
01

Overview

GTSE1 divergent transcript (GTSE1-DT) is a long noncoding RNA (lncRNA) transcribed from the region head-to-head (divergently) to the GTSE1 protein-coding locus. It does not encode a protein or function as a receptor, enzyme, or druggable molecular target. Aliases include GTSE1-AS1 and LL22NC03-5H6.6. No experimental evidence is currently available describing its precise biological function, its role in disease, or its utility as a biomarker or drug target. It is catalogued in gene databases under NCBI Gene ID 150384 and Ensembl ENSG00000277232. Most functional and disease associations described in the literature pertain to the protein GTSE1, not the divergent transcript GTSE1-DT. There is no evidence at present that drugs interact with GTSE1-DT, nor that it is included in any biomarker or therapeutic strategies. GTSE1-DT is a correctly named and annotated lncRNA, not a protein, receptor, enzyme, or conventional drug target.

Other names
CN5H6.4GTSE1-AS1LL22NC03-5H6.6GTSE1 antisense RNA 1 (head to head)
02

Biological functions

Not well defined; presumed regulatory RNA based on antisense orientation and the function of similar lncRNAs, but no definitive functional role or molecular mechanism is confirmed in the literature searched.
03

Disease associations

Unknown; direct disease links are not established for GTSE1-DT as of current knowledge, unlike the protein-coding GTSE1 gene which is implicated in various cancers.

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