Target intelligence / Profile preview

Guanine (O6 Position) on DNA

Molecular classification: Nucleobase, DNA Component

Overview

The O6 position of guanine refers to the oxygen atom attached to the sixth carbon of the guanine base in DNA. This site is a key target for alkylation and methylation damage, leading to mispairing with thymine during DNA replication and subsequent G:C → A:T transition mutations. It is primarily repaired by MGMT. Modification at this site is highly mutagenic and carcinogenic.

Mechanism of action

DNA damage by alkylation/methylation, leading to mispairing and mutations.

Biological functions

DNA base pairingGenetic information storageMutagenesis (when modified)

Disease associations

CancerGenetic disorders

Safety considerations

MutagenicityCarcinogenicity

Interacting drugs

Temozolomide (TMZ)

1 more in the full profile.

Biomarkers

MGMT expression levelsO6-methylguanine levels

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