Target intelligence / Profile preview

Guanine Base (G)

Target: G
Molecular classification: Nucleobase, Purine Derivative

Overview

Guanine is a purine nucleobase found in DNA and RNA, playing a crucial role in base pairing with cytosine through three hydrogen bonds. It contributes to the structural stability of DNA and is involved in various biochemical processes, including DNA replication and repair, and energy transfer via GTP. Guanine is not typically considered a therapeutic target but is essential for genetic integrity and cellular function.

Other names: Guanine NucleobasePurine Base

Mechanism of action

Not applicable as a therapeutic target.

Biological functions

DNA Structure and StabilityBase PairingGenetic Information EncodingEnergy Transfer (via GTP)

Disease associations

Cancer (due to mutations affecting guanine-cytosine pairing)Genetic Disorders (related to DNA stability and replication errors)

Safety considerations

Not applicable as a therapeutic target.

Interacting drugs

None specific to guanine itself, but drugs affecting DNA replication or stability might interact indirectly.

Biomarkers

None specific to guanine.

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