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Guanine N7 Position (N7-Guanine)
- Target
- N7-Guanine
- Molecular classification
- Nucleobase, DNA/RNA component, Modified Nucleobase (e.g., m^7G)
01
Overview
The N7 position of guanine refers to the nitrogen atom at the seventh position on the guanine base, one of the four main nucleobases in DNA and RNA. This site is highly nucleophilic and is a primary target for alkylation and adduct formation by various chemicals, including carcinogens and certain chemotherapeutic agents. N7-guanine adducts are frequently used as biomarkers to assess exposure to genotoxic agents. Methylation at this site also occurs naturally during mRNA capping (m^7G cap), which is essential for mRNA stability and translation initiation in eukaryotes.
- Other names
- Guanine N7N7 GuanineGuanine-N77-methylguanine (when methylated)
02
Mechanism of action
DNA alkylation/adduct formation
03
Biological functions
DNA/RNA structuremRNA cappingTarget for alkylationAdduct formation
04
Disease associations
Cancer (DNA damage)Exposure biomarker
05
Safety considerations
DNA damageMutagenesis (indirectly)Depurination
06
Interacting drugs
Cisplatin
1 more in the full profile.
07
Biomarkers
N7-guanine adducts
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