Guanine nucleotide-binding protein-like 3-like protein (GNL3L)

Guanine nucleotide-binding protein-like 3-like protein (GNL3L) is an evolutionarily conserved, high molecular weight nucleolar GTPase of the HSR1-MMR1 subfamily. It is predominantly localized to the nucleolus but shuttles between the nucleus and cytoplasm in a signal-mediated, CRM1-dependent fashion. GNL3L harbors functional nuclear import and export signals, with nucleolar targeting at its N-terminus and CRM1-interacting nuclear export at its C-terminus. Functionally, GNL3L modulates cell cycle progression by promoting S phase entry and progression, participating in ribosome biogenesis, and interacting with cell cycle regulators (e.g., the retinoblastoma protein/E2F1 axis). Its dysregulation has been associated with tumor-promoting activities, notably through stabilizing MDM2, an oncogenic factor, and inhibiting transcriptional co-activators. While GNL3L is not currently the target of clinical drugs, its central roles in proliferation and oncogenesis render it a candidate for future therapeutic studies[1][2].

Other names

GNL3LFLJ10613GNL3BG protein nucleolar 3Bguanine nucleotide-binding protein-like 3-like proteinguanine nucleotide binding protein-like 3 (nucleolar)-likenovel GTPase

No drugs identified as directly modulating GNL3L. Experimentally, Leptomycin B inhibits the CRM1-dependent export of GNL3L from the nucleus[1][2].