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Target intelligence / Profile preview
Guanine nucleotide-binding protein subunit alpha-11 (Gα11)
- Target
- Gα11
- Molecular classification
- G protein subunit, G protein-coupled receptor (GPCR) signaling component
01
Overview
GNA11 encodes the alpha subunit of a heterotrimeric G protein (Gα11), a key component in GPCR signaling. Upon activation, Gα11 activates phospholipase C beta (PLC-β), initiating intracellular signaling cascades that regulate diverse cellular processes like cell growth, division, apoptosis, and hormone secretion. Mutations in GNA11 are implicated in autosomal dominant hypocalcemia and uveal melanoma.
- Other names
- GNA11FBHFBH2FHH2guanine nucleotide binding protein (alpha 11 [or] q class)
02
Mechanism of action
GPCR signaling modulation, PLC-β activation, Calcium homeostasis regulation
03
Biological functions
Signal transductionPLC-β activationCalcium signalingRegulation of hormone secretionCell proliferationApoptosis
04
Disease associations
Autosomal Dominant Hypocalcemia Type 2HypoparathyroidismUveal MelanomaBlue Nevus
05
Safety considerations
Potential for off-target effects due to similarity to other Gq family membersMutations can lead to constitutive activation of downstream signaling pathways.
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