Guanine nucleotide-binding protein subunit alpha-14 (GNA14)

Guanine nucleotide-binding protein subunit alpha-14 is a member of the G protein alpha-q family (GNA14), functioning as part of the heterotrimeric G protein signaling complex. Upon activation of cell surface GPCRs, GNA14 facilitates GDP-GTP exchange and activates phospholipase C-beta, triggering hydrolysis of membrane phospholipids and release of intracellular messengers such as diacylglycerol (DAG) and inositol trisphosphate (IP3), resulting in activation of protein kinase C and calcium signaling. GNA14 is implicated in diverse physiological processes including platelet aggregation, cardiovascular regulation, glucose metabolism, and cell proliferation. It may play a role in disease states such as vascular tumors and cardiomyopathies, and pharmacological inhibition has demonstrated therapeutic potential in preclinical models.

Other names

GNA14G alpha-14Guanine nucleotide-binding protein subunit alpha-14G protein subunit alpha-14HG1IGuanine nucleotide-binding protein 14Heterotrimeric guanine nucleotide-binding protein 1I

Inhibition of GDP–GTP exchange to prevent downstream GNA14 signaling; Modulation of phospholipase C-beta and subsequent calcium/PKC signaling