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Guanine nucleotide-binding protein subunit alpha-15 (GNA15)
- Target
- GNA15
- Molecular classification
- G protein, signal transduction protein, heterotrimeric G protein alpha subunit (Gq class)
01
Overview
Guanine nucleotide-binding protein subunit alpha-15 (GNA15) is a member of the Gq alpha subunit family of heterotrimeric G proteins, which act as modulators or transducers in various transmembrane signaling systems. Upon activation by G protein-coupled receptors (GPCRs), GNA15 triggers downstream signaling events, particularly those related to calcium mobilization and phospholipase C activation. This protein is expressed in multiple tissues and has been implicated in the development of certain cancers and other signal transduction-related disorders
- Other names
- GNA15GNA16G alpha-15G-protein subunit alpha-15G alpha-16G-protein subunit alpha-16HG1Lepididymis tissue protein Li 17Eepididymis secretory sperm binding proteinheterotrimeric guanine nucleotide-binding protein 1L
02
Mechanism of action
Modulation of intracellular signaling cascades via G protein-coupled receptors (Gq pathway), activating downstream effectors such as phospholipase C and influencing calcium signaling
03
Biological functions
Signal transductionG protein-coupled receptor bindingcalcium-mediated signaling
04
Disease associations
Cancer (e.g., thyroid carcinoma)vibratory urticaria
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