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Guanine Quadruplex (None)
- Target
- None
- Molecular classification
- Nucleic acid secondary structure, DNA structure, RNA structure
01
Overview
Guanine quadruplexes are non-canonical nucleic acid structures formed from stacks of guanine tetrads, stabilized by monovalent cations. They are prevalent in telomeric regions and gene promoters, playing significant roles in gene regulation, telomere maintenance, and genome stability. Their involvement in controlling cell growth pathways makes them promising targets for anticancer therapies.
- Other names
- G-quadruplexG4
02
Mechanism of action
Stabilization of G-quadruplexes to inhibit telomerase activity or interfere with oncogene expression.
03
Biological functions
Gene regulationTelomere maintenanceGenome stability
04
Disease associations
Cancer
05
Safety considerations
Off-target effects due to structural polymorphismLimited understanding of in vivo effects of G4 stabilization
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