Target intelligence / Profile preview

Guanine Residue

Molecular classification: Nucleobase, Purine

Overview

Guanine is one of the four main nitrogenous bases found in DNA and RNA. In DNA, guanine always pairs with cytosine via three hydrogen bonds, contributing significantly to the stability of the double helix. Guanine residues are fundamental components of DNA's informational code, and changes or damage at these sites can have significant biological consequences. Beyond its structural role, guanine participates indirectly in cellular signaling through molecules like GTP (guanosine triphosphate) and plays roles in energy transfer reactions.

Biological functions

Encodes genetic informationMaintains DNA helical stabilityEnergy transfer (as GTP)Cell signaling

Disease associations

Cancer (indirectly, via mutations)Mutagenesis

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