Guanine residue in DNA (G (when referring to the base), but no standard abbreviation for "guanine residue in DNA" as a target)

A **guanine residue** in DNA refers to an individual molecule of **guanine**, one of four nitrogenous bases found within deoxyribonucleic acid. Guanine is a purine nucleobase that pairs specifically with cytosine via three hydrogen bonds, contributing significantly to the stability and information content encoded by double-stranded DNA. While essential for genetic function and integrity, isolated “guanine residues” are not themselves therapeutic targets; rather they serve as fundamental building blocks within genes. Some anticancer agents exploit chemical reactivity at these sites—such as alkylating agents—but do so non-specifically across all accessible instances throughout genomic material rather than targeting unique molecular entities.

Other names

Guanine baseG basePurine base GNucleobase guanine

For drugs that interact with guanine bases in DNA: - Alkylation/crosslinking at specific positions on the purine ring disrupts replication/transcription leading to cell death.