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Guanine Residue in DNA Minor Groove
- Molecular classification
- DNA, Nucleobase, Nucleic Acid Component
01
Overview
A guanine residue in the DNA minor groove refers to the presence and chemical environment of a guanine base as it is exposed within the narrower, shallower groove formed by the double helix structure of B-form DNA. It influences DNA structure, protein binding, and ligand interactions. The purine 2-amino group (on guanine) is a primary determinant controlling intrinsic width of the DNA minor groove.
- Other names
- Guanine in minor grooveMinor groove guanineGuanine N2 amino groupDNA minor groove guanine
02
Biological functions
DNA structure maintenanceDNA recognitionProtein-DNA interactionLigand-DNA interactionGene regulation
03
Disease associations
Cancer (indirectly, via gene regulation)Genetic disorders (indirectly, via gene regulation)
04
Interacting drugs
Distamycin
1 more in the full profile.
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