Guanosine monophosphate reductase pseudogene

Guanosine monophosphate reductase pseudogene is a nonfunctional DNA sequence in the human genome homologous to the functional guanosine monophosphate reductase gene (GMPR or GMPR2). Pseudogenes like this arise from gene duplication or retrotransposition events; they typically contain mutations that prevent generation of a functional protein. While they resemble true genes in sequence, they are not transcribed and translated into functional proteins, and have no established role as therapeutic targets, biomarkers, or drug receptors[2]. The canonical therapeutic enzyme is "Guanosine monophosphate reductase" (GMPR or GMPR2), which participates in nucleotide metabolism and is a functional enzyme[1][3][4][6][7]. This entry refers exclusively to a pseudogene, not the active gene or its protein product. The Ensembl identifier ENSG00000224692, when checked against current genomic databases, specifically labels this entry as a pseudogene. If structured information is required for a druggable target, one should refer to the functional gene (e.g., GMPR or GMPR2), not the pseudogene[4][6][7].

Other names

GMPR pseudogeneGMPRP