Guanylate-binding protein 7 (GBP7)

Guanylate-binding protein 7 (GBP7) is a member of the GBP family of interferon-inducible large GTPases involved in the innate immune response. GBP7 hydrolyzes GTP to GDP and GMP and is upregulated in response to interferon signaling, particularly during infection. It plays a critical regulatory role in host defense against intracellular pathogens—including viruses, bacteria, and protozoa—by modulating cytokine-mediated immune signaling. Notably, in the context of influenza A virus infection, GBP7 expression is increased, and it acts as a negative regulator of host antiviral cytokine responses by suppressing type I and III interferon expression as well as proinflammatory cytokines through inhibition of the NF-κB and JAK-STAT signaling pathways. GBP7 may also facilitate assembly of NADPH oxidase on phagosomal membranes, supporting a role in oxidative burst responses to pathogens. GBP7 is encoded by the GBP7 gene (Gene ID: 388646) in humans. There are currently no clinically approved drugs known to target GBP7 directly, nor is it a validated biomarker, but its role in viral pathogenesis and innate immune regulation suggests potential as a host-directed therapeutic target.

Other names

Guanylate-binding protein 7GBP7GBP4LGBP-7FLJ38822GTP-binding protein 7Guanine nucleotide-binding protein 7Guanylate-binding protein 4-like