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Target intelligence / Profile preview
Guanylyl Cyclase (GC)
- Target
- GC
- Molecular classification
- Enzyme, Lyase
01
Overview
Guanylyl cyclase is an enzyme that catalyzes the conversion of guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP), a critical second messenger involved in numerous physiological processes. It exists in two main forms: soluble guanylyl cyclases (sGC), activated by nitric oxide, and membrane-bound/particulate guanylyl cyclases, activated by peptide hormones. cGMP generated via guanylyl cyclase signaling acts as an intracellular second messenger with diverse roles in smooth muscle cells, neurons, kidneys/intestines/retina/bone/cartilage.
- Other names
- Guanylate CyclaseGuanyl Cyclase
02
Mechanism of action
Catalyzes the conversion of guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP), a critical second messenger involved in numerous physiological processes. Soluble guanylyl cyclase is activated by nitric oxide binding to its heme group.
03
Biological functions
Signal transductionRegulation of vasodilationRegulation of ion transportModulation of synaptic transmission and plasticityRegulation of fluid balanceRegulation of vision adaptationRegulation of skeletal growth
04
Disease associations
HypertensionHeart failureErectile dysfunctionRetinal degeneration disorders
05
Interacting drugs
YC‑1
1 more in the full profile.
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