Guanylate cyclase 1 soluble subunit alpha-1 (GUCY1A1)

Guanylate cyclase 1 soluble subunit alpha-1 (GUCY1A1) is the alpha subunit of the soluble (cytosolic) guanylate cyclase enzyme complex. This enzyme is a heterodimer composed of alpha and beta subunits, acting as the primary receptor for nitric oxide (NO) in human cells. Upon binding NO, the active enzyme catalyzes the conversion of GTP to cyclic GMP (cGMP), a crucial signaling molecule involved in regulating vascular tone, platelet aggregation, and cellular proliferation. Mutations in GUCY1A1 have been implicated in Moyamoya disease and other vasculopathies. Approved drugs such as riociguat and vericiguat target this enzyme to promote vasodilation in pulmonary hypertension and heart failure.

Other names

1200016O07RikAlpha 1 GCGC-1alphaGC-1αGC-SA3GC-S-alpha-1GCS-alpha-3GC-S-α-1GCS-α-3guanylate cyclase 1, soluble, alpha 1Guanylate cyclase 1, soluble, alpha 3guanylate cyclase 1 soluble subunit alpha 1guanylate cyclase 1 soluble subunit α 1guanylate cyclase 1, soluble, α 1Guanylate cyclase 1, soluble, α 3GUANYLATE CYCLASE alpha 1GUANYLATE CYCLASE α 1GUC1A3GUCA3GUCSA3GUCY1A3MYMY6NO-GC1NO receptor guanylyl cyclase alpha1 subunitSGCsGC-alpha1SGC-α-1α 1 GC

- Activation of soluble guanylate cyclase by nitric oxide increases conversion of GTP to cGMP, leading to vasodilation - Direct stimulation of the enzyme by pharmacological stimulators (riociguat, vericiguat) even in reduced NO states