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Guanylate cyclase 1 soluble subunit alpha-2 (GUCY1A2)
- Target
- GUCY1A2
- Molecular classification
- Enzyme, Soluble guanylate cyclase subunit
01
Overview
Guanylate cyclase 1 soluble subunit alpha-2 (GUCY1A2) encodes an alpha subunit of soluble guanylate cyclase, forming an active heterodimer (usually with the beta-1 subunit) that catalyzes the conversion of GTP to cyclic GMP (cGMP), a crucial second messenger in nitric oxide signaling. This enzyme is widely expressed, with especially high expression in neural tissues, and regulates vascular tone, neurotransmission, and other cGMP-dependent physiological processes. Dysfunction or altered regulation of GUCY1A2 may contribute to neurological conditions and cardiovascular disorders[1][2][4][5][6][7].
- Other names
- Guanylate cyclase soluble subunit alpha-2GUCY1A2GUC1A2GUCSA2GCS-alpha-2GC-SA2
02
Mechanism of action
Allosteric stimulation by nitric oxide (NO) leading to increased cGMP production Direct activation or modulation by small molecule stimulators (e.g., riociguat, which sensitize or stimulate soluble guanylate cyclase)
03
Biological functions
Signal transductioncGMP synthesis (conversion of GTP to cyclic GMP)Nitric oxide signaling
04
Disease associations
Cardiovascular diseaseNemaline myopathyPotential roles in neurobiology and other diseases through nitric oxide signaling
05
Safety considerations
Excessive hypotension (low blood pressure) due to vasodilationDrug interactions in combination with nitrates or phosphodiesterase inhibitors (risk of severe hypotension)
06
Interacting drugs
Sildenafil (Viagra)
2 more in the full profile.
07
Biomarkers
Circulating cyclic GMP (cGMP) as a pharmacodynamic marker for NO-sGC pathway activation
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