Guanylate cyclase 1 soluble subunit beta-1 (GUCY1B1)

Guanylate cyclase 1 soluble subunit beta-1 is a catalytic subunit of soluble guanylate cyclase (sGC), an enzyme critical for nitric oxide (NO) signaling in human physiology. It forms a heterodimer with the alpha subunit (typically sGCα1), and together this enzyme acts as the primary cellular receptor for nitric oxide. Upon binding NO, the heme-containing domain in the beta-1 subunit facilitates a conformational change, dramatically increasing sGC's catalytic efficiency to convert GTP to cGMP, a second messenger that mediates smooth muscle relaxation, vasodilation, neurotransmission, and inhibition of platelet aggregation. Dysregulation or dysfunction of this enzyme system is relevant to cardiovascular, neurodegenerative, and proliferative diseases. It is a validated drug target for approved vasodilators and sGC stimulators.

Other names

Gc70GCbeta1GC-SB3GC-S-beta-1GC-S-β-1GCYB1guanylate cyclase 1, soluble, beta 1guanylate cyclase 1 soluble subunit β 1guanylate cyclase 1, soluble, β 1GUC1B3GUCB3GUCSB3GUCY1B3NO-GC beta 1Nogc beta1 subunitNO-GC β 1NO receptor guanylyl cyclase beta1 subunitSGCSgc beta-1SGC-β-1

Drugs stimulate guanylate cyclase activity, increasing cGMP production by mimicking or enhancing the action of nitric oxide or directly activating the enzyme