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Target intelligence / Profile preview
Guanylate cyclase 2C (GC-C)
- Target
- GC-C
- Molecular classification
- Transmembrane receptor enzyme, Receptor, Enzyme, Guanylate cyclase
01
Overview
Guanylate cyclase 2C (GUCY2C), also known as guanylyl cyclase C (GC-C), is a transmembrane receptor enzyme primarily expressed in the intestinal epithelium and a subset of hypothalamic neurons. Upon binding to its ligands, such as guanylin, uroguanylin, or E. coli heat-stable enterotoxin, it catalyzes the production of cGMP, a second messenger that regulates fluid and electrolyte balance and intestinal epithelial homeostasis. GUCY2C is a therapeutic target and biomarker for gastrointestinal malignancies, particularly colorectal cancer.
- Other names
- Guanylyl cyclase CIntestinal guanylate cyclaseHeat-stable enterotoxin receptorhSTARDIAR6GUC2CMECILMUCIL
02
Mechanism of action
Catalyzes conversion of GTP to cGMP, activating downstream signaling cascades.
03
Biological functions
Regulation of fluid and electrolyte secretionMaintenance of intestinal epithelial homeostasisCell proliferationDNA integrityBarrier functionSignal transduction
04
Disease associations
Colorectal cancerGastrointestinal malignanciesChronic idiopathic constipationTraveler's diarrhea
05
Safety considerations
Hyperactivation leading to excessive fluid and electrolyte secretion (e.g., traveler's diarrhea)Potential dysregulation of cGMP signaling
06
Interacting drugs
Drugs that elevate cGMP levels
07
Biomarkers
GUCY2C expression in colorectal cancerMinimal residual disease in colorectal cancer
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