Guanylate cyclase 2G pseudogene (GUCY2GP)

Guanylate cyclase 2G pseudogene (GUCY2GP) refers to a non-functional, inactivated human genomic sequence homologous to the active mouse gene Gucy2g, which encodes a receptor guanylyl cyclase enzyme. In mice, Gucy2g is involved in cyclic GMP synthesis and is predicted to play a role in guanylyl cyclase signaling[4]. In humans, this gene is disabled and does not produce a functional protein, thus it is classified as a unitary pseudogene[3]. There is no evidence supporting any biological function, disease association, or pharmacological relevance for the human GUCY2GP locus; it is not considered a therapeutic target.\n\nKey details:\n- **Pseudogene status** means the human gene is incapable of normal protein-coding function due to ancestral disabling mutations[3].\n- There is no established role in normal physiology or disease in humans.\n- No drugs target this molecule and it is not relevant for drug action, safety, or as a biomarker.\n\nNo authoritative databases list this pseudogene as a valid drug target, and it should not be confused with the homologous, functional guanylyl cyclases in other species[3][4].

Other names

GUCY2Gguanylate cyclase 2G homologpseudogeneGUCY2GP