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Target intelligence / Profile preview
Guanylate cyclase soluble subunit alpha-1 (sGCα1)
- Target
- sGCα1
- Molecular classification
- Enzyme, Receptor
01
Overview
Guanylate cyclase soluble subunit alpha-1 (sGCα1) is a subunit of the heterodimeric soluble guanylate cyclase (sGC) enzyme, a primary receptor for nitric oxide (NO). Upon NO binding, sGC catalyzes the conversion of GTP to cGMP, a second messenger involved in vasorelaxation and other physiological processes. Therapeutic agents targeting sGC, such as riociguat and vericiguat, stimulate cGMP production for the treatment of cardiovascular diseases.
- Other names
- GUCY1A3GUC1A3GCYA1
02
Mechanism of action
sGC stimulators that enhance cGMP production
03
Biological functions
Signal transductionVasorelaxationRegulation of vascular toneInhibition of platelet aggregationModulation of cell proliferationModulation of cell survivalCatalysis
04
Disease associations
Cardiovascular diseaseCoronary artery diseaseMoyamoya diseaseMyocardial infarction
05
Interacting drugs
Riociguat
1 more in the full profile.
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