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Target intelligence / Profile preview
Guanylate cyclase soluble subunit alpha-2 (GC-SA2)
- Target
- GC-SA2
- Molecular classification
- Enzyme
01
Overview
Guanylate cyclase soluble subunit alpha-2 is a component of the soluble guanylyl/guanylate cyclase (sGC) enzyme complex. sGC catalyzes the conversion of GTP to cyclic GMP (cGMP) in response to nitric oxide (NO) signaling. cGMP acts as a second messenger involved in various physiological processes including vasodilation, smooth muscle relaxation, platelet aggregation inhibition, and neurotransmission. Dysregulation or mutations affecting sGC function have implications in cardiovascular diseases. Pharmacological activators/stimulators targeting sGC are being explored for therapeutic use.
- Other names
- GUCY1A2GUC1A2guanylate cyclase 1, soluble, alpha 2
02
Mechanism of action
sGC stimulators activate the enzyme to increase cGMP production.
03
Biological functions
Signal transductionVasodilationSmooth muscle relaxationPlatelet aggregation inhibitionNeurotransmissioncGMP production
04
Disease associations
Cardiovascular diseaseHypertensionHeart failure
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